During the time of the Clone Wars, the Pantoran Guard served to enforce their claim to Orto Plutonia, the planet around which their homeworld orbited as a moon. In 22 BBY, when the Republic lost contact with their outpost on the frozen planet of Orto Plutonia, two Pantoran Guards accompanied chairman Chi Cho and Senator Riyo Chuchi along with Jedi Generals Obi-Wan Kenobi and Anakin Skywalker to the planet to investigate.
Upon learning that the native Talz were behind the attack on both the Republic and Separatist outposts, Cho declared war on the Talz. As a result, he, his guards and his Clone Trooper escort fell under attack from the natives. The pair of Cho's guards fought against the Talz to the best of their abilities in the poor defensive position, but were both killed.