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Mother Talzin, the spiritual guide of Dathomir's Nightsisters during the Clone Wars, held enormous power on her homeworld and wielded the strange magics of the dark side of the Force.
When Asajj Ventress was betrayed and broken, Talzin took Ventress in and when Asajj told her the whole story, she immediately had a plan. Talzin got two other Nightsisters, Naa'leth and Karis, to assist Asajj in an assassination attempt. Using magic to make the trio invisible and arming them with Jedi lightsabers and a special poisonous dart, Talzin sent them to attack Dooku at his estate on Serenno. When the attempt failed Mother Talzin used the attack as opportunity to offer Dooku a new apprentice manipulating the Sith Lord's new found paranoia brought about by his nearly being killed in his own home. When Ventress found a candidate, Savage Opress, he would become Dooku's new apprentice, but his real job was to eliminate Dooku for Talzin and Ventress.